| This project focuses on the development and application of reversibly compressible 3D implants based on biocompatible polymers characterized by a hierarchically structured porous texture with supportive and regenerative capabilities. During the implementation of the project, several research outputs are planned in the field of fabrication of hierarchically structured porous 3D scaffolds based on fibroin, collagen and polycaprolactone with defined biological properties with respect to cell adhesion, proliferation and differentiation to achieve tissue replacement with the most natural physiology and functionality under in vivo conditions. The proposed biocompatible implants will exhibit controlled degradation without inducing a significant inflammatory response. The main application of the developed scaffolds is their use as nerve conduits for peripheral nerve regeneration in neurology and neurosurgery. |