Tomas Bata University in Zlín

Pyridin-2-one derivatives exhibit various biological activities, due to which they play an important role not only in medicine but also in agriculture to ensure the production of both plant and animal foods, and are also used as synthons for other heterocyclic compounds.¹ Their subset, natural and synthetic 4-hydroxypyridin-2-ones, is also characterized by a diversity of biological activities,^2,3 whose synthetic use is, however, so far much less explored than that of their benzologs, 4-hydroxyquinolin-2-ones.⁴ The aim of the thesis will be to prepare a series of 4-hydroxypyridin-2-ones by described or as yet undescribed procedures, to study their transformations into as yet undescribed compounds, the composition and structure of which will be confirmed by modern analytical methods (NMR, MS, or X-ray structural analysis) and to subject the prepared compounds to available tests of their effects on microorganisms attacking agricultural products, foodstuffs or food crops.

1. Sangwan, S.; Yadav, N.; Kumar, R.; Chauhan, S.; Dhanda, V.; Walia, P.; Duhan, A. A score years’ update in the synthesis and biological evaluation of medicinally important 2-pyridones. J. Med. Chem. 2022, 232, 114199
2. Jessen, H. J.; Gademann, K. 4-Hydroxy-2-pyridone alkaloids: Structures and synthetic approaches. Prod. Rep. 2010, 27, 1168-1185.
3. Zhao, S.; Huang, J.; Cheng, J.; Liu, B.; Chen, C. Progress in the synthesis of 4- hydroxy-2-pyridone derivatives. Youji Huaxue 2012, 32, 651-660.
4. Proisl, K.; Kafka, S.; Košmrlj, J. Chemistry and applications of 4-hydroxyquinolin- 2-one and quinoline-2,4-dione-based compounds. Org. Chem. 2017, 21, 1949- 1975.